母羊钙摄入过量导致胎儿骨软骨病。
Osteochondrosis in fetuses of ewes overfed calcium.
作者信息
Corbellini C N, Krook L, Nathanielsz P W, Kallfelz F A
机构信息
Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.
出版信息
Calcif Tissue Int. 1991 Jan;48(1):37-45. doi: 10.1007/BF02555794.
Ewes were fed ad libitum (up to maximum of 2.5 kg/day) a complete feed containing either 1.52% calcium (High Ca) or 0.59% calcium (Normal Ca) on a dry matter basis from day 50 of pregnancy, and the fetuses were removed at 133-135 days. Thyroid C cells, identified by indirect immunofluorescence, were more numerous (P less than 0.001) and plasma levels of 24,25-dihydroxycholecalciferol [24,25(OH)2D] were higher (P less than 0.09) in fetuses of High Ca ewes. These fetuses also had retarded cartilage differentiation in the proximal humeral epiphysis and metaphysis as well as transverse trabeculation in the epiphysis. These entities are two of the hallmarks of osteochondrosis. It was shown that feeding high dietary calcium to pregnant ewes caused osteochondrosis in their fetuses. Hypercalcitoninism and/or an adverse effect of supraphysiological levels of 24,25-dihydroxycholecalciferol may have been contributory to the skeletal abnormalities.
从怀孕第50天起，给母羊随意喂食（最多2.5千克/天）一种干物质基础上含钙量为1.52%（高钙组）或0.59%（正常钙组）的全价饲料，在133 - 135天时取出胎儿。通过间接免疫荧光鉴定的甲状腺C细胞，在高钙组母羊的胎儿中数量更多（P < 0.001），且24,25 - 二羟胆钙化醇[24,25(OH)2D]的血浆水平更高（P < 0.09）。这些胎儿在肱骨近端骨骺和干骺端的软骨分化也延迟，骨骺处还有横向小梁形成。这些表现是骨软骨病的两个特征。研究表明，给怀孕母羊喂食高钙日粮会导致其胎儿患骨软骨病。高降钙素血症和/或超生理水平的24,25 - 二羟胆钙化醇的不良影响可能是骨骼异常的原因。
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