Jarzab B, Kokot F, Bałdys A
Acta Endocrinol (Copenh). 1984 Apr;105(4):567-70. doi: 10.1530/acta.0.1050567.
Immunoreactive calcitonin (I-CT) was assayed in rat thyroid glands from foetuses with a gestational age of 15.5-22 days. The mean content of the hormone was 455.0 +/- 35.8 ng/gland. A positive linear correlation was found between the I-CT content in the thyroid glands and the gestational age of the foetuses. I-CT was also present in rat placentae from 10.5-21.5 days old pregnancies. A mean placental concentration of 4.5 +/- 1.2 ng I-CT/mg wet tissue was found. The highest hormone concentrations were observed in placentae from 10.5 day old foetuses, displaying a progressive fall during the further course of pregnancy. It is concluded that the rat foetal thyroid gland produces I-CT beginning from a gestational age of 15.5 days'. The need for further investigations into a possible role of CT in transplacental calcium transport is also indicated.
对胎龄为15.5 - 22天的大鼠胎儿甲状腺中的免疫反应性降钙素（I - CT）进行了测定。该激素的平均含量为455.0±35.8 ng/腺体。甲状腺中I - CT含量与胎儿胎龄之间存在正线性相关。在妊娠10.5 - 21.5天的大鼠胎盘中也检测到了I - CT。发现胎盘的平均浓度为4.5±1.2 ng I - CT/mg湿组织。在胎龄10.5天的胎盘组织中观察到最高的激素浓度，在妊娠后期逐渐下降。得出的结论是，大鼠胎儿甲状腺从胎龄15.5天开始产生I - CT。同时也表明有必要进一步研究降钙素在经胎盘钙转运中可能发挥的作用。
