Mozafari M R
Phosphagenics R&D Laboratory, Clayton, VIC, Australia.
Methods Mol Biol. 2010;605:29-50. doi: 10.1007/978-1-60327-360-2_2.
Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated to nanoliposomes is immense, ranging from pharmaceuticals to cosmetics and nutraceuticals. Because of their biocompatibility and biodegradability, along with their nanosize, nanoliposomes have potential applications in a vast range of fields, including nanotherapy (e.g. diagnosis, cancer therapy, gene delivery), cosmetics, food technology and agriculture. Nanoliposomes are able to enhance the performance of bioactive agents by improving their solubility and bioavailability, in vitro and in vivo stability, as well as preventing their unwanted interactions with other molecules. Another advantage of nanoliposomes is cell-specific targeting, which is a prerequisite to attain drug concentrations required for optimum therapeutic efficacy in the target site while minimising adverse effects on healthy cells and tissues. This chapter covers nanoliposomes, particularly with respect to their properties, preparation methods and analysis.
纳米脂质体，即亚微米双层脂质囊泡，是一种用于生物活性剂包封和递送的新技术。可纳入纳米脂质体的生物活性材料种类繁多，从药物到化妆品和营养保健品不等。由于其生物相容性和生物降解性，以及纳米尺寸，纳米脂质体在广泛的领域具有潜在应用，包括纳米治疗（如诊断、癌症治疗、基因递送）、化妆品、食品技术和农业。纳米脂质体能够通过提高生物活性剂的溶解度、生物利用度、体外和体内稳定性，以及防止它们与其他分子发生不必要的相互作用，来增强其性能。纳米脂质体的另一个优点是细胞特异性靶向，这是在靶位点达到最佳治疗效果所需的药物浓度，同时将对健康细胞和组织的不良影响降至最低的先决条件。本章涵盖纳米脂质体，特别是关于它们的性质、制备方法和分析。
