Yi Cheng-xue, Yu Jiang-nan, Xu Xi-ming
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):1936-40.
Nanocarriers generally made of natural or artificial polymers ranging in size from about 10-1 000 nm, possess versatile properties suitable for drug delivery, including good biocompatibility and biodegradability, potential capability of targeted delivery and controlled release of incorporated drugs, and have been extensively used in the development of new drug delivery systems (DDS). These types of nano-DDS have considerable potential to traditional Chinese medicine (TCM), and recently have attracted increasing efforts on the TCM research and development. In this review, the recently published literature worldwide is covered to describe the latest advances in the applications as TCM delivery carriers, and to highlight the characteristics and preparation methods of some selected examples of promising nanocarriers such as nanoparticles, lipid nanoparticles, nanoemulsions, nanomicelles and nanoliposomes.
纳米载体通常由大小约为10 - 1000纳米的天然或人工聚合物制成，具有适用于药物递送的多种特性，包括良好的生物相容性和生物降解性、所载药物靶向递送和控释的潜在能力，并且已广泛用于新型药物递送系统（DDS）的开发。这类纳米DDS对中药具有相当大的潜力，最近在中药研发方面吸引了越来越多的努力。在本综述中，涵盖了全球最近发表的文献，以描述作为中药递送载体应用的最新进展，并突出一些有前景的纳米载体（如纳米颗粒、脂质纳米颗粒、纳米乳剂、纳米胶束和纳米脂质体）的选定实例的特性和制备方法。
