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脂质体囊泡制备技术与结构——图文综述

Niosome Preparation Techniques and Structure-An Illustrated Review.

作者信息

Mawazi Saeid Mezail, Ge Yi, Widodo Riyanto Teguh

机构信息

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

School of Pharmacy, Management and Science University, Shah Alam 40100, Selangor, Malaysia.

出版信息

Pharmaceutics. 2025 Jan 6;17(1):67. doi: 10.3390/pharmaceutics17010067.

DOI:10.3390/pharmaceutics17010067
PMID:39861715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768252/
Abstract

A comprehensive review of recent research on niosomes was conducted using a mixed methodology, including searches in databases such as Scopus, PubMed, and Web of Science (WoS). Articles were selected based on relevance. The current review examines the historical development of niosomes focusing on the methods of preparations and the contemporary strategies and prospective advancements within the realm of drug delivery systems, highlighting innovative approaches across transdermal, oral, and cellular delivery. This review reported the method of niosomes preparations including a new and novel approach for the preparation of niosomes known as the ball milling method (BM). This technique allows for the precise manipulation of size and shape, leading to improvements in drug release, encapsulation efficiency, and uniformity compared to traditional methods. Niosomes can serve as carriers for delivering various types of drugs, including hydrophobic, hydrophilic, and amphiphilic. This improves the efficiency of encapsulating different drugs, the size of targeted particles, and the desired zeta potential. This is achieved by using a specific charge-inducing agent for drug delivery and targeting specific diseases. These efforts are crucial for overcoming the current limitations and unlocking the full therapeutic potential of modern medicine.

摘要

采用混合方法对近期有关非离子表面活性剂囊泡的研究进行了全面综述，包括在Scopus、PubMed和科学网（WoS）等数据库中进行检索。根据相关性筛选文章。本综述考察了非离子表面活性剂囊泡的历史发展，重点关注其制备方法以及药物递送系统领域的当代策略和未来进展，突出了经皮、口服和细胞递送方面的创新方法。本综述报道了非离子表面活性剂囊泡的制备方法，包括一种制备非离子表面活性剂囊泡的全新方法，即球磨法（BM）。与传统方法相比，该技术能够精确控制尺寸和形状，从而改善药物释放、包封效率和均匀性。非离子表面活性剂囊泡可用作递送各种类型药物的载体，包括疏水性、亲水性和两亲性药物。这提高了不同药物的包封效率、靶向颗粒的大小以及所需的zeta电位。这是通过使用特定的电荷诱导剂进行药物递送和靶向特定疾病来实现的。这些努力对于克服当前的局限性和释放现代医学的全部治疗潜力至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/1f595eaac60f/pharmaceutics-17-00067-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e911b73a201f/pharmaceutics-17-00067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e8d5f356a58c/pharmaceutics-17-00067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/eec0f004fa5d/pharmaceutics-17-00067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/bde03324111f/pharmaceutics-17-00067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/8c006a6cbf03/pharmaceutics-17-00067-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/1ccb096028bd/pharmaceutics-17-00067-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/7c3a7e793f9a/pharmaceutics-17-00067-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e1efe8119d9b/pharmaceutics-17-00067-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/3d1274f079db/pharmaceutics-17-00067-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/11b16007512f/pharmaceutics-17-00067-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/02a534c49d0d/pharmaceutics-17-00067-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/52a5980084d0/pharmaceutics-17-00067-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/f322463770db/pharmaceutics-17-00067-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/9b87f10c7704/pharmaceutics-17-00067-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/1f595eaac60f/pharmaceutics-17-00067-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e911b73a201f/pharmaceutics-17-00067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e8d5f356a58c/pharmaceutics-17-00067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/eec0f004fa5d/pharmaceutics-17-00067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/bde03324111f/pharmaceutics-17-00067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/8c006a6cbf03/pharmaceutics-17-00067-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/1ccb096028bd/pharmaceutics-17-00067-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/7c3a7e793f9a/pharmaceutics-17-00067-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/e1efe8119d9b/pharmaceutics-17-00067-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/3d1274f079db/pharmaceutics-17-00067-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/11b16007512f/pharmaceutics-17-00067-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/02a534c49d0d/pharmaceutics-17-00067-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/52a5980084d0/pharmaceutics-17-00067-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/f322463770db/pharmaceutics-17-00067-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/9b87f10c7704/pharmaceutics-17-00067-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e6/11768252/1f595eaac60f/pharmaceutics-17-00067-g015.jpg

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[5]
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[6]
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本文引用的文献

[1]
Comparative Study of Lycopene-Loaded Niosomes Prepared by Microfluidic and Thin-Film Hydration Techniques for UVB Protection and Anti-Hyperpigmentation Activity.

Int J Mol Sci. 2024-10-31

[2]
Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers.

Pharmaceutics. 2024-3-21

[3]
Evaluating a targeted Palbociclib-Trastuzumab loaded smart niosome platform for treating HER2 positive breast cancer cells.

Int J Pharm X. 2024-3-11

[4]
Optimization of a Luteolin-Loaded TPGS/Poloxamer 407 Nanomicelle: The Effects of Copolymers, Hydration Temperature and Duration, and Freezing Temperature on Encapsulation Efficiency, Particle Size, and Solubility.

Cancers (Basel). 2023-7-24

[5]
Cyclodextrin modified niosomes to encapsulate hydrophilic compounds.

RSC Adv. 2018-8-23

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Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research.

Pharmaceutics. 2021-9-22

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Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies.

Nanomedicine. 2021-10

[8]
Fabrication and Applications of Microfluidic Devices: A Review.

Int J Mol Sci. 2021-2-18

[9]
Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control.

Foods. 2020-9-26

[10]
Sodium dodecyl sulfate improved stability and transdermal delivery of salidroside-encapsulated niosomes via effects on zeta potential.

Int J Pharm. 2020-4-30

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