Eyer C L, Johnson W E
J Pharm Sci. 1977 Oct;66(10):1450-3. doi: 10.1002/jps.2600661026.
The fetal rat heart in organ culture was used to investigate rate chanes by various cardioactive agents. Concomitantly, the effect of these pharmacologically induced rate changes on steady-state cyclic adenosine monophosphate levels was determined. Isoproterenol increased the fetal rat heart rate and cyclic adenosine monophosphate in a concentration-related fashion. Quinidine produced a concentration-related decrease in heart rate and no change in cyclic adenosine monophosphate level. The dysrhythmogenic agent produced concentration-related negative chronotropism in the fetal rat heart preparation and significant elevations in cyclic adenosine monophosphate at concentrations without chronotropic action. No correlation between chronotropic effect of a drug and cyclic adenosine monophosphate levels was observed.
采用器官培养的胎鼠心脏来研究各种心脏活性药物引起的心率变化。同时，测定这些药理学诱导的心率变化对稳态环磷酸腺苷水平的影响。异丙肾上腺素以浓度相关的方式增加胎鼠心率和环磷酸腺苷。奎尼丁使心率呈浓度相关下降，而环磷酸腺苷水平无变化。致心律失常药物在胎鼠心脏标本中产生浓度相关的负性变时作用，且在无变时作用的浓度下使环磷酸腺苷显著升高。未观察到药物的变时作用与环磷酸腺苷水平之间存在相关性。
