Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Anal Chem. 2010 Feb 15;82(4):1221-7. doi: 10.1021/ac902008x.
In this paper, we present an innovative sensing nanomaterial for an interference localized surface plasmon resonance (iLSPR) sensor. The iLSPR is based on plasmonic gold nanoparticles with photonic thin-film multilayers of porous aluminum oxide (Al(2)O(3)) and aluminum (Al) on a substrate. With a controllable transparent Al(2)O(3) layer and a highly reflective Al layer, our new nanomaterial was able to detect refractive index (RI) changes of the surrounding environment and the specific interaction of biomolecules including biotin and avidin, 5- fluorouracil (5-FU) and its antibody, anti-5-fluorouracil (anti 5-FU), when the iLSPR surfaces were biologically functionalized. Our model nanostructure will open the way to display the plasmonic properties of other noble metal nanoparticles and to develop other functionally similar nanosensors, which could then be expanded into multiarrays.
在本文中，我们提出了一种用于干涉局域表面等离子体共振（iLSPR）传感器的创新传感纳米材料。iLSPR 基于具有光子薄膜多层多孔氧化铝（Al2O3）和衬底上的铝（Al）的等离子体金纳米粒子。通过可控透明的 Al2O3 层和高反射的 Al 层，我们的新型纳米材料能够检测周围环境的折射率（RI）变化以及生物分子的特定相互作用，包括生物素和亲和素、5-氟尿嘧啶（5-FU）及其抗体、抗 5-氟尿嘧啶（抗 5-FU），当 iLSPR 表面进行生物功能化时。我们的模型纳米结构将为展示其他贵金属纳米粒子的等离子体特性以及开发其他功能类似的纳米传感器开辟道路，然后可以将其扩展为多阵列。
