Golubov J, Flanagan P, Adams P
Department of Medicine, University Hospital, University of Western Ontario, London, Canada.
Dig Dis Sci. 1991 Apr;36(4):405-8. doi: 10.1007/BF01298866.
Since gastric acid is an important luminal factor in the absorption of non-heme iron, the effect of omeprazole on the absorption of iron in a rat model was studied. Iron absorption studies were performed on rats on a normal diet (N = 42) and rats fed an iron-deficient diet (N = 43) for three weeks. Rats were orally dosed with 40 mumol/kg of omeprazole or placebo daily for two days prior to iron absorption studies. Rats were orally dosed with 1 mmol of ferrous chloride, ferric chloride or food iron (dietary suspension) containing 11 micrograms of iron and labeled with 1 microCi of 59Fe. Omeprazole-treated rats on the normal diet had no significant reduction in the absorption of ferric, ferrous, or food iron. In the rats on the iron-deficient diet, the absorption of ferrous iron decreased from 76 +/- 7.5% (mean +/- SE) in control rats to 38 +/- 8.5% in the omeprazole-treated rats (P less than 0.003) and the absorption of food iron decreased from 65 +/- 7.5% in control rats to 37 +/- 6.5% in the omeprazole-treated rats (P less than 0.016). There was no significant reduction in the absorption of ferric iron. Omeprazole therapy is unlikely to be associated with significant iron malabsorption in normal patients but may reduce iron absorption in pathological states associated with increased iron absorption such as iron deficiency.
由于胃酸是影响非血红素铁吸收的一个重要腔内因素，因此研究了奥美拉唑对大鼠模型中铁吸收的影响。对正常饮食的大鼠（N = 42）和缺铁饮食喂养3周的大鼠（N = 43）进行了铁吸收研究。在铁吸收研究前两天，大鼠每天口服40 μmol/kg的奥美拉唑或安慰剂，持续两天。大鼠口服1 mmol氯化亚铁、氯化铁或含11微克铁并标记有1微居里59Fe的食物铁（膳食悬浮液）。正常饮食的奥美拉唑治疗组大鼠对三价铁、二价铁或食物铁的吸收没有显著降低。在缺铁饮食的大鼠中，二价铁的吸收从对照大鼠的76±7.5%（平均值±标准误）降至奥美拉唑治疗组大鼠的38±8.5%（P<0.003），食物铁的吸收从对照大鼠的65±7.5%降至奥美拉唑治疗组大鼠的37±6.5%（P<0.016）。三价铁的吸收没有显著降低。奥美拉唑治疗在正常患者中不太可能导致明显的铁吸收不良，但在与铁吸收增加相关的病理状态如缺铁中可能会降低铁的吸收。
