每日口服奥美拉唑对24小时胃内酸度的影响。
Effect of daily oral omeprazole on 24 hour intragastric acidity.
作者信息
Walt R P, Gomes M D, Wood E C, Logan L H, Pounder R E
出版信息
Br Med J (Clin Res Ed). 1983 Jul 2;287(6384):12-4. doi: 10.1136/bmj.287.6384.12.
Abstract
Twenty four hour intragastric acidity was measured in nine patients with duodenal ulcer before and after one week of treatment with oral omeprazole 30 mg daily, a drug that inhibits gastric secretion by inhibition of parietal cell H+K+ adenosinetriphosphatase (ATPase). Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily.
摘要
对9例十二指肠溃疡患者在口服每日30毫克奥美拉唑治疗一周前后测量了24小时胃内酸度。奥美拉唑是一种通过抑制壁细胞H⁺K⁺三磷酸腺苷酶（ATP酶）来抑制胃酸分泌的药物。奥美拉唑几乎消除了所有患者的胃内酸度：24小时胃内pH值中位数从1.4升至5.3，每小时氢离子活性均值从38.50降至1.95毫摩尔（毫当量）/升（p<0.001）。这种对24小时胃内酸度的抑制比先前报道的每日服用1克西咪替丁或每日服用300毫克雷尼替丁更为显著。
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