Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Biochem Soc Trans. 2010 Feb;38(Pt 1):237-41. doi: 10.1042/BST0380237.
Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing.
核 RNA 加工是真核基因表达的一个关键阶段，部分受核 RNA 结合蛋白的表达和浓度控制。不同的核 RNA 结合蛋白在不同的细胞中表达不同，帮助剪接体将前体 mRNA 解码为选择性剪接的 mRNA。最近的后基因组技术揭示了核 RNA 加工的复杂性，并开始揭示 RNA 结合蛋白网络调节多个平行途径的机制和规则。鉴定由核 RNA 结合蛋白调节的多个平行加工途径，正在导致对替代核 RNA 加工的规则和后果的系统全面理解。
