Marnay-Gulat C, Tuong M D, Labitte A
J Physiol (Paris). 1977 Oct;73(5):653-62.
Decreased hypercalcemic effects of PTH are observed after medulloadrenalectomy, (table I), metoprione (table II) or cortisone (table IV) treatments in guinea pigs. 2. Norepinephrine restores the blood calcium effects of PTH in these cases but epinephrine is inactive. 3. Immediate activation of kidney adenylate cyclase by PTH (increased urinary AMPc) is also reduced in medulloadrenalectomised, cortisone or metopirone treated guinea pigs (table V). But in this test, norepinephrine reduces the effect of PTH (fig. 1).
在豚鼠接受肾上腺髓质切除术(表I)、美替拉酮(表II)或可的松(表IV)治疗后,观察到甲状旁腺激素(PTH)的高钙血症效应降低。2. 在这些情况下,去甲肾上腺素可恢复PTH的血钙效应,但肾上腺素无此作用。3. 在接受肾上腺髓质切除术、可的松或甲吡酮治疗的豚鼠中,PTH对肾腺苷酸环化酶的即时激活作用(尿中AMPc增加)也降低了(表V)。但在该试验中,去甲肾上腺素可降低PTH的作用(图1)。