Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, Maryland 20993, USA.
Ann N Y Acad Sci. 2009 Dec;1182:146-60. doi: 10.1111/j.1749-6632.2009.05158.x.
Cytokines encompass a wide variety of proteins that can trigger many cellular activities. An important set of cytokines modulate inflammatory responses (inflammatory cytokines). These molecules have potent biological activities and have been a major focus for protein drug development. There have been both successes and failures in this area. Initial hurdles, such as limited manufacturing capacity, have now been largely overcome. However clinical development remains a challenge. On the basis of the history of cytokine therapeutics, a number of strategies for future drug development are considered.
细胞因子包含多种可触发多种细胞活动的蛋白质。一组重要的细胞因子调节炎症反应（炎症细胞因子）。这些分子具有很强的生物学活性，一直是蛋白质药物开发的重点。在这一领域既有成功也有失败。最初的障碍，如有限的生产能力，现在在很大程度上已经克服了。然而，临床开发仍然是一个挑战。根据细胞因子治疗的历史，考虑了一些未来药物开发的策略。
