Khatkhatay I, Desai M P, Sankolli G M, Meherji P K, Joshi U M
Endocrinology and Infertility Clinic, Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
Eur J Obstet Gynecol Reprod Biol. 1991 Feb 25;38(3):213-6. doi: 10.1016/0028-2243(91)90294-u.
Corpus luteal function was assessed by estimating pregnanediol 3-alpha-glucuronide (PdG) in three midluteal-phase urine samples collected from 85 women attending the infertility clinic. The previously established cut off limits based on PdG estimations were useful in detecting anovulation in 23 cases, corpus luteal adequacy in 42 cases and corpus luteum deficiency (CLD) in 20 cases. In 8 women CLD could be corrected with 50 mg of clomiphene citrate (CC) therapy whereas 6 women required 100 mg of CC and 3 pregnancies were achieved. This rapid screening method is thus useful in segregating a large number of women according to their ovulatory status and in the subsequent treatment of CLD.
通过测定85名不孕门诊女性在黄体中期采集的三份尿液样本中的孕二醇3-α-葡萄糖醛酸苷（PdG）来评估黄体功能。先前基于PdG测定确定的临界值有助于检测出23例无排卵、42例黄体功能正常和20例黄体功能不足（CLD）的情况。8名CLD女性通过50mg枸橼酸氯米芬（CC）治疗得到纠正，而6名女性需要100mg CC治疗，并有3例成功妊娠。因此，这种快速筛查方法有助于根据排卵状态对大量女性进行分类，并用于后续CLD的治疗。
