Brastianos Priscilla K, Batchelor Tracy T
Department of Medical Oncology, Dana-Farber/Brigham and Women's Cancer Center, Massachusetts General Hospital, Boston, 02114, USA.
Clin Adv Hematol Oncol. 2009 Nov;7(11):753-60, 768.
Glioblastomas are highly vascular tumors. Recent preclinical and clinical investigations have demonstrated that agents targeting angiogenesis may have efficacy in this type of tumor. Antibodies to vascular endothelial growth factor (VEGF), VEGF receptor tyrosine kinase inhibitors, immunomodulatory agents, and soluble decoy VEGF receptors are being studied in this patient population. Unfortunately, treatment inevitably fails. Further studies are needed to understand mechanisms of tumor resistance and to identify other therapeutic targets that mediate angiogenesis.
胶质母细胞瘤是高度血管化的肿瘤。最近的临床前和临床研究表明，靶向血管生成的药物可能对这类肿瘤有效。血管内皮生长因子（VEGF）抗体、VEGF受体酪氨酸激酶抑制剂、免疫调节剂以及可溶性VEGF受体诱饵正在该患者群体中进行研究。不幸的是，治疗不可避免地会失败。需要进一步研究以了解肿瘤耐药机制，并确定介导血管生成的其他治疗靶点。
