血清尿酸与中国工作场所人群主动脉僵硬度和压力的关系。

Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting.

机构信息

Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

出版信息

Am J Hypertens. 2010 Apr;23(4):387-92. doi: 10.1038/ajh.2009.277. Epub 2010 Jan 14.

DOI:10.1038/ajh.2009.277

PMID:20075845

Abstract

BACKGROUND

In the present analysis, we investigated the association of serum uric acid with aortic stiffness and pressure as measured by carotid-femoral pulse wave velocity (cf-PWV) and central systolic blood pressure (SBP), respectively.

METHODS

Our study was conducted in the framework of cardiovascular health examinations for the employees of a factory and their family members (ages 15-79 years). We performed arterial measurements using the SphygmoCor device. Hyperuricemia was defined as a serum uric acid concentration of at least 420 micromol/l in men and 360 micromol/l in women.

RESULTS

The 940 study participants included 207 (22.0%) hypertensive patients, of whom 92 (9.8%) took antihypertensive medication. Men (n = 620), compared with women (n = 320), had significantly (P < or = 0.03) higher serum uric acid concentration (363 +/- 76 vs. 272 +/- 64 micromol/l), prevalence of hyperuricemia (17.9% vs. 7.5%), cf-PWV (7.41 vs. 7.16 m/s), and central SBP (114.4 vs. 108.8 mm Hg). Both before and after adjustment for age, serum uric acid was significantly (P < or = 0.02) and positively associated with cf-PWV and central SBP in all subjects and in men and women separately. After full adjustment for covariates, the association with cf-PWV remained statistically significant (P < or = 0.009) in all subjects and men, and with central SBP in all subjects only. Categorical analyses were confirmatory. In all subjects, patients with hyperuricemia had significantly (P = 0.03) higher cf-PWV (7.51 vs. 7.29 m/s) and central SBP (114.9 vs. 112.1 mm Hg) than those with normal serum uric acid.

CONCLUSIONS

Serum uric acid was associated with aortic stiffness and pressure in a Chinese workplace setting, especially in men.

摘要

背景

在本分析中，我们研究了血清尿酸与分别通过颈股脉搏波速度（cf-PWV）和中心收缩压（SBP）测量的主动脉僵硬和压力之间的关系。

方法

我们的研究是在一家工厂的员工及其家属（年龄 15-79 岁）的心血管健康检查框架内进行的。我们使用 SphygmoCor 设备进行动脉测量。高尿酸血症定义为男性血清尿酸浓度至少为 420μmol/L，女性为 360μmol/L。

结果

940 名研究参与者包括 207 名（22.0%）高血压患者，其中 92 名（9.8%）服用降压药物。男性（n=620）与女性（n=320）相比，血清尿酸浓度（363±76 对 272±64μmol/L）、高尿酸血症患病率（17.9%对 7.5%）、cf-PWV（7.41 对 7.16m/s）和中心 SBP（114.4 对 108.8mmHg）均显著升高（P<0.03）。在调整年龄后，所有受试者、男性和女性的血清尿酸与 cf-PWV 和中心 SBP 均呈显著（P<0.02）和正相关。在充分调整协变量后，所有受试者和男性的 cf-PWV 与尿酸之间的关联仍具有统计学意义（P<0.009），而仅在所有受试者中与中心 SBP 相关。分类分析是验证性的。在所有受试者中，高尿酸血症患者的 cf-PWV（7.51 对 7.29m/s）和中心 SBP（114.9 对 112.1mmHg）均显著高于正常血清尿酸患者（P=0.03）。