Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX, USA.
Am J Hypertens. 2010 Apr;23(4):420-4. doi: 10.1038/ajh.2009.274. Epub 2010 Jan 14.
Prenatal programming of hypertension has been described in humans and in animal models that receive a prenatal insult, but the mechanism for the increase in blood pressure remains elusive.
In male rats whose mothers received dexamethasone between days 15 and 18 of gestation systemic and urinary levels of angiotensin II were measured to determine whether angiotensin II was a potential factor for the generation (4 weeks of age) or maintenance (8 weeks of age) of hypertension.
A group 4- and 8-week-old male rats that were the product of a pregnancy where the mother received prenatal dexamethasone between days 15 and 18 of gestation had comparable plasma renin and angiotensin II levels to the offspring of vehicle-treated controls. Renal angiotensin II levels were not different at 4 and 8 weeks of age between the controls and the prenatal dexamethasone group. Urine angiotensin II/Creatinine levels, a reflection of filtered and renally generated and secreted angiotensin II, were higher at both 4 and 8 weeks of age in male rats that received prenatal dexamethasone compared to controls.
The high-urine angiotensin II levels in prehypertensive and hypertensive rats that were the product of mothers that received dexamethasone compared to vehicle suggest that luminal angiotensin II may play a role in the generation and maintenance of hypertension in this model of prenatal programming.
在接受产前刺激的人类和动物模型中，已经描述了高血压的产前编程，但血压升高的机制仍不清楚。
在其母亲在妊娠第 15 至 18 天接受地塞米松的雄性大鼠中，测量了血管紧张素 II 的全身和尿水平，以确定血管紧张素 II 是否是产生（4 周龄）或维持（8 周龄）高血压的潜在因素。
一组 4 周和 8 周龄的雄性大鼠，其母亲在妊娠第 15 至 18 天接受了产前地塞米松，其血浆肾素和血管紧张素 II 水平与接受载体处理的对照组的后代相当。在 4 周和 8 周龄时，对照组和产前地塞米松组之间的肾脏血管紧张素 II 水平没有差异。尿血管紧张素 II/肌酐水平，反映了过滤和肾脏生成和分泌的血管紧张素 II，在接受产前地塞米松的雄性大鼠中，在 4 周和 8 周龄时均高于对照组。
与接受载体的对照组相比，接受地塞米松的母亲所生的预高血压和高血压大鼠的高尿血管紧张素 II 水平表明，管腔血管紧张素 II 可能在该产前编程模型中高血压的产生和维持中起作用。
