Zelickson B D, Muller S A
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):186-94. doi: 10.1016/0190-9622(91)70025-w.
Generalized pustular psoriasis is rare in children. Less than 100 cases have been reported. We describe 13 children with this type of psoriasis. Seven had acute onset of widespread sterile pustules coalescing into lakes of pus with subsequent exfoliation (the Zumbusch pattern). This usually occurred in infancy and was difficult to control; recurrences developed several times per year. Three had the subacute benign annular pattern. They tended to be older and often had resolution within several years. Three had a mixed pattern with Zumbusch flares preceded by an annular or acral pattern. Most patients had an eruption preceding the generalized pustular psoriasis and often had precipitating factors. Generally, generalized pustular psoriasis has little serious chronic morbidity. The condition in most patients was well controlled with topical therapy. Systemic steroids were not helpful.
泛发性脓疱型银屑病在儿童中较为罕见。报告的病例不足100例。我们描述了13例患有此类银屑病的儿童。7例急性起病，广泛的无菌脓疱融合成脓湖，随后出现脱屑（即祖姆布施型）。这通常发生在婴儿期，且难以控制；每年会复发数次。3例呈现亚急性良性环状型。他们年龄偏大，通常在数年内病情会缓解。3例为混合型，在环状或肢端型之后出现祖姆布施型皮疹发作。大多数患者在泛发性脓疱型银屑病之前有皮疹发作，且往往有诱发因素。一般来说，泛发性脓疱型银屑病很少有严重的慢性发病情况。大多数患者的病情通过局部治疗得到了良好控制。全身用类固醇药物并无帮助。
