Zelickson B D, Muller S A
Department of Dermatology, Mayo Clinic, Rochester, Minn. 55905.
Arch Dermatol. 1991 Sep;127(9):1339-45.
Sixty-three patients with generalized pustular psoriasis were hospitalized during a 29-year period. They were classified into four subgroups on the basis of onset and morphologic pattern of disease: acute (von Zumbusch), subacute annular, chronic (acral), and mixed. This division provides a better understanding of the variability of the disease and helps in choosing treatment.
The average age at onset was 50 years; male and female patients were affected about equally. In 11 patients, flares were precipitated by localized infections. Approximately one fourth of the patients had complications; most were superinfections. The average stay in the hospital was 30 days; factors correlating with a long hospitalization were hypocalcemia, female sex, and a previous history of psoriasis vulgaris or pustular psoriasis.
Whereas topical therapy was helpful, systemic medications were often needed. Coal tar, ultraviolet light, and psoralen-ultraviolet A may be effective; however, they must be used with caution, because they may exacerbate the disease.
在29年期间，63例泛发性脓疱型银屑病患者住院治疗。根据疾病的起病情况和形态学模式，将他们分为四个亚组：急性（冯·祖姆布施型）、亚急性环状、慢性（肢端型）和混合型。这种分类有助于更好地理解该疾病的变异性，并有助于选择治疗方法。
发病的平均年龄为50岁；男性和女性患者受影响的程度大致相同。11例患者因局部感染而病情加重。约四分之一的患者有并发症；大多数是继发感染。平均住院时间为30天；与长期住院相关的因素有低钙血症、女性以及寻常型银屑病或脓疱型银屑病的既往病史。
虽然局部治疗有帮助，但通常需要使用全身药物。煤焦油、紫外线和补骨脂素 - 紫外线A可能有效；然而，必须谨慎使用，因为它们可能会使病情加重。
