Trattner A, Lurie R, Leiser A, David M, Hazaz B, Kadish U, Sandbank M
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):223-6. doi: 10.1016/0190-9622(91)70031-v.
Eleven newly diagnosed patients and one patient with pemphigus vulgaris who relapsed underwent endoscopy of the upper gastrointestinal tract. Three patients had blisters or erosions and two had longitudinal lines of erythema in the esophageal mucosa. In four patients histopathologic examination showed findings of pemphigus vulgaris but direct immunofluorescence was positive in all patients. This study demonstrates that the immunopathologic disturbance in pemphigus vulgaris involves the entire length of the esophagus, although only some patients have clinical or histologic involvement. To the best of our knowledge this is the first histopathologic and direct immunofluorescence study of esophageal involvement in patients with untreated pemphigus vulgaris.
11例新诊断患者和1例复发的寻常型天疱疮患者接受了上消化道内镜检查。3例患者食管黏膜有水疱或糜烂，2例有纵行红斑线。4例患者组织病理学检查显示寻常型天疱疮表现，但所有患者直接免疫荧光均为阳性。本研究表明，寻常型天疱疮的免疫病理紊乱累及食管全长，尽管只有部分患者有临床或组织学受累。据我们所知，这是首次对未经治疗的寻常型天疱疮患者食管受累进行的组织病理学和直接免疫荧光研究。
