自噬在病毒复制和发病机制中的作用。
Autophagy in viral replication and pathogenesis.
机构信息
Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
出版信息
Mol Cells. 2010 Jan;29(1):1-7. doi: 10.1007/s10059-010-0014-2. Epub 2010 Jan 8.
Abstract
Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived proteins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pathogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.
摘要
自噬是一种重要的分解代谢过程，可清除受损的细胞器和长寿蛋白，以维持细胞内的稳态。它还可以作为先天免疫来清除细胞内的微生物病原体。越来越多的病毒已被证明会影响这一细胞途径。一些病毒为了生存而抑制这一途径，而另一些病毒则增强或利用这一途径来促进其复制。病毒对自噬的影响也可能使细胞对死亡敏感，或增强细胞存活，并在病毒发病机制中发挥关键作用。本文综述了不同病毒与自噬之间的关系，并讨论了这些关系如何影响病毒及其宿主细胞。
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