U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, North Carolina 27709, USA.
J Toxicol Environ Health A. 2010;73(2):108-13. doi: 10.1080/15287390903337084.
This article on the U.S. Environmental Protection Agency document, "Framework for Metals Risk Assessment" (U.S. EPA, 2007a) was presented at the "Health Risk Assessment of Essential Metals" Workshop held at the University of Ottawa in May 2008. This article discusses the basic principles included in the Framework for Metals Risk Assessment and outlines how these principles need to be considered in human health and ecological risk assessment practices. Recognizing that metals present unique risk assessment issues, the article includes discussion of the various scientific issues related to metals assessments, such as environmental chemistry, bioavailability, bioaccumulation, and essentiality.
这篇文章是对美国环境保护署文件“金属风险评估框架”（U.S. EPA，2007a）的解读，曾在 2008 年 5 月于渥太华大学举办的“必需金属的健康风险评估”研讨会上发表。本文讨论了金属风险评估框架中包含的基本原则，并概述了在人类健康和生态风险评估实践中应如何考虑这些原则。鉴于金属具有独特的风险评估问题，本文还讨论了与金属评估相关的各种科学问题，例如环境化学、生物利用度、生物积累和必需性。
