Guler A K, Gunaldi O, Alis H, Tugcu B, Tanriverdi O, Colluoglu B
Bakirkoy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Istanbul, Turkey.
Minim Invasive Neurosurg. 2009 Oct;52(5-6):246-9. doi: 10.1055/s-0029-1238276. Epub 2010 Jan 14.
Neurofibroma occurs as an isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). Neurofibroma is a benign peripheral nerve sheath tumor composed of a variable mixture of Schwann, perineurial-like, and fibroblastic cells, as well as ones with features intermediate between these various cells, immersed in a collagenous or myxoid matrix.
A 10-year-old boy visited the outpatient clinic with complaints of swelling and pain on the left side of his neck, which has been present for a year. A mass was discovered adjacent to the left internal carotid artery (ICA) and was removed by a microsurgical technique. No postoperative neurological deficit was identified and the pathological diagnosis was once more reported as neurofibroma.
Nerve sheath tumors may be observed in patients with von Recklinghausen's disease, although vagal neurofibromas are noted more frequently than schwannomas among these patients. For unknown reasons, neoplasms associated with von Recklinghausen's disease occur more frequently on the right side. Cervical vagal neurofibromas most often present as asymptomatic, slowly enlarging, lateral neck masses. When symptoms are observed, hoarseness is the most common. Dysphonia, dyspnea, dysphagia, cough, syncopal episodes, tongue weakness and atrophy, and Horner's syndrome have also been reported as presenting complaints.
神经纤维瘤可作为孤立性或多发性病变出现，常与1型神经纤维瘤病（NF-1）相关。神经纤维瘤是一种良性周围神经鞘瘤，由施万细胞、类神经束膜细胞和成纤维细胞的可变混合物组成，以及具有介于这些不同细胞之间特征的细胞，浸润于胶原或黏液样基质中。
一名10岁男孩因左侧颈部肿胀和疼痛前来门诊就诊，症状已持续一年。在左颈内动脉（ICA）旁发现一个肿块，并通过显微外科技术将其切除。术后未发现神经功能缺损，病理诊断再次报告为神经纤维瘤。
在冯雷克林霍增氏病患者中可观察到神经鞘瘤，尽管在这些患者中迷走神经纤维瘤比施万细胞瘤更常见。原因不明的是，与冯雷克林霍增氏病相关的肿瘤在右侧更常见。颈迷走神经纤维瘤最常表现为无症状、缓慢增大的颈部外侧肿块。出现症状时，声音嘶哑最为常见。也有报道称发音困难、呼吸困难、吞咽困难、咳嗽、晕厥发作、舌肌无力和萎缩以及霍纳综合征为就诊主诉。
