Division of General Surgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Phytother Res. 2010 Feb;24(2):189-92. doi: 10.1002/ptr.2905.
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
姜黄素可以通过诱导人肺癌 NCI-H460 细胞凋亡来减少活细胞。然而，没有报道称姜黄素可以在体内抑制癌细胞。在这项研究中，将 NCI-H460 肺肿瘤细胞直接植入裸鼠体内，并随机分为四组，分别用载体、姜黄素（30mg/kg 体重）、姜黄素（45mg/kg 体重）和阿霉素（8mg/kg 体重）治疗。每种药物每隔 4 天通过腹腔内（i.p.）注射一次，从接种 NCI-H460 细胞后 4 周开始治疗。与对照组相比，用 30mg/kg 和 45mg/kg 的姜黄素或 8mg/kg 的阿霉素治疗可降低肿瘤发生率、大小和重量。这些发现表明，姜黄素可以抑制体内 NCI-H460 异种移植动物模型中的肿瘤生长。
