Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Pediatr Blood Cancer. 2010 May;54(5):764-7. doi: 10.1002/pbc.22393.
Cytogenetic information of non-ossifying fibromas (NOFs) is exceptionally limited. This fact relies, in part, on their benign nature but mainly because most cases evolve undetected or there is no need for surgical intervention. We report the case of a NOF arising in the left tibia of a 14-year-old male with an invariable clonal translocation. The karyotype was denoted as 42-46,XY,t(11;3;14)(q23;p21;p11). There are only two previous reported cases of clonally aberrant NOF. Records from additional cases will be essential to assess whether consistent karyotypic aberrations define this lesion.
非骨化性纤维瘤（NOF）的细胞遗传学信息极其有限。这一事实部分归因于其良性性质，但主要是因为大多数病例在未被察觉的情况下发展，或者不需要手术干预。我们报告了一例发生在 14 岁男性左胫骨的非骨化性纤维瘤，存在不变的克隆易位。核型表示为 42-46，XY，t（11；3；14）（q23;p21;p11）。仅有两例先前报道的克隆性异常非骨化性纤维瘤病例。额外病例的记录对于评估是否一致的核型异常定义该病变至关重要。
