Saltzberg D M, Kotloff K L, Newman J L, Fastiggi R
Department of Medicine, University of Maryland School of Medicine, Baltimore.
J Clin Gastroenterol. 1991 Feb;13(1):94-7. doi: 10.1097/00004836-199102000-00021.
Chronic diarrhea and malabsorption accompanied by simultaneous infection with the protozoa Giardia lamblia and Cryptosporidium occurred in a 22-year-old homosexual man with antibody to human immunodeficiency virus (HIV). Small bowel biopsy demonstrated total villous atrophy and marked mononuclear infiltration in the lamina propria simulating celiac disease. Treatment with metronidazole resulted in resolution of diarrhea, clearance of parasites, and marked improvement in small bowel histology. Although diarrhea and malabsorption in immunocompromised patients with cryptosporidiosis are regarded as ominous, our patient remained disease free for the next 3 years. Thus, infection with Cryptosporidium in patients with HIV does not always lead to intractable diarrhea or death.
一名22岁感染人类免疫缺陷病毒（HIV）的同性恋男子出现慢性腹泻和吸收不良，并同时感染了原生动物兰氏贾第鞭毛虫和隐孢子虫。小肠活检显示全绒毛萎缩，固有层有明显的单核细胞浸润，类似乳糜泻。甲硝唑治疗使腹泻症状缓解，寄生虫清除，小肠组织学显著改善。尽管免疫功能低下的隐孢子虫病患者出现腹泻和吸收不良被认为预后不佳，但我们的患者在接下来的3年里未再发病。因此，HIV患者感染隐孢子虫并不总是导致顽固性腹泻或死亡。
