Ungar B L, Ward D J, Fayer R, Quinn C A
Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Gastroenterology. 1990 Feb;98(2):486-9. doi: 10.1016/0016-5085(90)90842-o.
Cryptosporidium is a parasite of the human gastrointestinal tract that can cause life-threatening diarrhea in immunodeficient patients. Although more than 80 agents have been tried with occasional anecdotal success, treatment remains primarily limited to hydration. A 38-yr-old homosexual man with antibody to human immunodeficiency virus and Cryptosporidium-related diarrhea is described. The patient excreted 6-12 L of stool per day for at least 3 mo, 2 of them spent in the hospital. Trials with more than 6 antidiarrheal medications were ineffective. The patient received bovine colostrum hyperimmune to Cryptosporidium by direct duodenal infusion. During infusion, the patient's fecal output decreased to less than 2 L per day, and 48 h after treatment, stools were formed and oocysts to Cryptosporidium were absent. The patient remained asymptomatic for 3 mo. Hyperimmune bovine colostrum offers an exciting new therapy for cryptosporidiosis; controlled trials to establish efficacy should be undertaken and the active factor(s) characterized.
隐孢子虫是一种寄生于人类胃肠道的寄生虫，可在免疫功能低下的患者中引起危及生命的腹泻。尽管已经尝试了80多种药物，偶尔有一些传闻称取得了成功，但治疗主要仍限于补液。本文描述了一名38岁的同性恋男子，他感染了人类免疫缺陷病毒并患有与隐孢子虫相关的腹泻。该患者每天排出6至12升粪便，至少持续了3个月，其中2个月住院治疗。使用6种以上止泻药物进行试验均无效。该患者通过十二指肠直接输注接受了对隐孢子虫具有高免疫性的牛初乳。在输注过程中，患者的粪便排出量降至每天少于2升，治疗48小时后，粪便成形且未发现隐孢子虫卵囊。该患者在3个月内一直无症状。高免疫牛初乳为隐孢子虫病提供了一种令人兴奋的新疗法；应进行对照试验以确定其疗效，并对活性因子进行鉴定。
