颈动脉内膜中层厚度的决定因素：芬兰东部男性基于人群的超声检查研究

Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern Finnish men.

作者信息

Salonen R, Salonen J T

机构信息

Research Institute of Public Health, University of Kuopio, Finland.

出版信息

J Intern Med. 1991 Mar;229(3):225-31. doi: 10.1111/j.1365-2796.1991.tb00336.x.

DOI:10.1111/j.1365-2796.1991.tb00336.x

PMID:2007840

Abstract

We investigated the determinants of maximal intima-media thickness of common carotid arteries in a population-based sample of 1224 Eastern Finnish men aged 42, 48, 54 or 60 years. A high-resolution B-mode ultrasonographic examination was performed as part of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). The maximal intima-media thickness (IMT) varied between 0.48 mm and 4.09 mm (mean value +/- SD, 0.94 mm +/- 0.38 mm). Age (standardized partial coefficient, beta = 0.238, P less than 0.0001), ambulatory pulse pressure (beta = 0.130, P less than 0.0001), cigarette-years of smoking (beta = 0.125, P less than 0.0001), serum LDL cholesterol concentration (beta = 0.125, P less than 0.0001), history of ischaemic heart disease (beta = 0.125, P less than 0.0001), pre-exercise systolic blood pressure (beta = 0.070, P = 0.0113) and diabetes (beta = 0.068, P = 0.0072) were most strongly associated with IMT. This study confirms the role of systolic blood pressure, smoking and serum LDL cholesterol levels as major risk factors for increased carotid intima-media thickness.

摘要

我们在一个基于人群的样本中，对1224名年龄为42、48、54或60岁的东芬兰男性进行了颈总动脉最大内膜中层厚度决定因素的调查。作为库奥皮奥缺血性心脏病危险因素研究（KIHD）的一部分，进行了高分辨率B型超声检查。最大内膜中层厚度（IMT）在0.48毫米至4.09毫米之间变化（平均值±标准差，0.94毫米±0.38毫米）。年龄（标准化偏系数，β = 0.238，P < 0.0001）、动态脉压（β = 0.130，P < 0.0001）、吸烟年包数（β = 0.125，P < 0.0001）、血清低密度脂蛋白胆固醇浓度（β = 0.125，P < 0.0001）、缺血性心脏病史（β = 0.125，P < 0.0001）、运动前收缩压（β = 0.070，P = 0.0113）和糖尿病（β = 0.068，P = 0.0072）与IMT的相关性最强。这项研究证实了收缩压、吸烟和血清低密度脂蛋白胆固醇水平作为颈动脉内膜中层厚度增加的主要危险因素的作用。