Misaki Marine Biological Station, Graduate School of Science and Center for Marine Biology, The University of Tokyo, 1024 Koajiro, Misaki, Miura, Kanagawa 238-0225, Japan.
Dev Growth Differ. 2010 Jan;52(1):57-68. doi: 10.1111/j.1440-169X.2009.01159.x.
Regeneration is a biological phenomenon that occurs in a wide range of animals, and is considered to involve different types of cells including those that are considered to be stem cells. Among the echinoderms, which is a phylum with many regenerating members, crinoids (feather stars and sea lilies) are known to possess high potential of regeneration and are able to regenerate most of their organs. In particular, arm regeneration has been studied using the feather star. During regeneration, coelomocytes and amoebocytes originating from the coelomic canal and the brachial nerve, respectively, migrate to the distal wound area and are involved in the regenerative process. A blastema is formed at the regenerating tip and is derived from migratory amoebocytes. On the other hand, migratory coelomocytes contribute to regenerate the coelomic system. Cells proliferate at the blastema, coelomic canals and brachial nerve. Since the migrating cells differentiate into new structures of the arm, they are considered presumably undifferentiated multipotent stem cells. To deepen our understanding of stem cells in general, we may benefit from an approach from a comparative point of view. Further molecular analyses would increase our knowledge of stem cells in crinoids and allow comparative studies to be possible.
再生是一种广泛存在于动物中的生物学现象，被认为涉及到不同类型的细胞，包括被认为是干细胞的细胞。在棘皮动物门中，有许多具有再生能力的成员，海百合（海百合和海羊齿）被认为具有很高的再生潜力，能够再生其大部分器官。特别是，使用海百合来研究腕足再生。在再生过程中，分别来自体腔管和腕神经的体腔细胞和变形细胞迁移到远端伤口区域，并参与再生过程。在再生的尖端形成芽基，来源于迁移的变形细胞。另一方面，迁移的体腔细胞有助于再生体腔系统。细胞在芽基、体腔管和腕神经中增殖。由于迁移细胞分化为腕足的新结构，它们被认为是未分化的多能干细胞。为了更深入地了解一般的干细胞，我们可以从比较的角度来研究。进一步的分子分析将增加我们对海百合中干细胞的认识，并允许进行比较研究。
