Medina-Feliciano Joshua G, García-Arrarás José E
University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.
Front Cell Dev Biol. 2021 Dec 17;9:768641. doi: 10.3389/fcell.2021.768641. eCollection 2021.
Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa.
哪些基因和基因信号通路介导再生过程？近年来，多项使用各种动物模型的研究旨在回答这个问题。通过转录组学和基因组学研究已经获得了一些答案，其中确定了可能参与组织和器官再生的基因和基因通路候选者。其中一些研究是在棘皮动物中进行的，棘皮动物是与脊椎动物一起构成后口动物一部分的动物群体。棘皮动物具有出色的再生能力，能够为再生的分子基础提供重要见解。在这里，我们回顾现有数据，以确定已被提出参与再生过程的基因和信号通路。我们的分析提供了一份经过整理的基因和基因信号通路列表，并将它们与再生反应的不同细胞过程进行匹配。通过这种方式，揭示了棘皮动物再生潜力的分子基础，可用于与其他动物类群进行比较。
