NFATc1 在根尖病变中的关键作用。
Critical role of NFATc1 in periapical lesions.
机构信息
Department of Operative Dentistry and Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
出版信息
Int Endod J. 2010 Feb;43(2):109-14. doi: 10.1111/j.1365-2591.2009.01649.x.
AIM
To observe NFATc1 expression in experimental periapical lesions in rats.
METHODOLOGY
Apical periodontitis was induced in Wistar rats by occlusal pulp exposure in mandibular first molar teeth. After exposure, 30 rats were killed on days 0, 7, 14, 21 and 28. The jaws that contained the first molar were removed and prepared for histological examination, immunohistochemistry and enzyme histochemistry.
RESULTS
From day 0 to day 28, the areas of periapical bone loss and the number of NFATc1-positive cells increased, peaking on day 28. The number of TRAP-positive cells increased substantially from day 0 to day 14 and then gradually decreased from day 14 to day 28.
CONCLUSIONS
NFATc1 was detected and possibly involved in the inflammatory response and bone resorption of periapical tissues, as well as being associated with periapical lesion pathogenesis.
目的
观察 NFATc1 在大鼠实验性根尖病变中的表达。
方法
通过在下颌第一磨牙的牙髓暴露来诱导 Wistar 大鼠根尖周炎。暴露后，在第 0、7、14、21 和 28 天处死 30 只大鼠。取出含第一磨牙的颌骨，进行组织学检查、免疫组织化学和酶组织化学检查。
结果
从第 0 天到第 28 天，根尖骨丧失面积和 NFATc1 阳性细胞数量增加，在第 28 天达到峰值。TRAP 阳性细胞数量从第 0 天到第 14 天显著增加，然后从第 14 天到第 28 天逐渐减少。
结论
检测到 NFATc1 并可能参与根尖组织的炎症反应和骨吸收，与根尖病变的发病机制有关。
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