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儿童特发性脊柱侧弯手术后深静脉血栓形成的筛查:一项试点研究。

Screening for deep venous thrombosis after idiopathic scoliosis surgery in children: a pilot study.

作者信息

Kaabachi Olfa, Alkaissi Ali, Koubaa Walid, Aloui Nadia, Toumi Nour El Houda

机构信息

Department of Anaesthesiology and Intensive Care Medicine, Kassab Orthopaedic Institute, Tunis, Tunisia.

出版信息

Paediatr Anaesth. 2010 Feb;20(2):144-9. doi: 10.1111/j.1460-9592.2009.03237.x.

Abstract

BACKGROUND

Venous thrombosis remains an uncommon disorder in childhood. However, the incidence appears to be increasing for a multitude of reasons. The aim of the study was to detect asymptomatic deep venous thrombosis and prothrombotic diseases in nonsyndromic children undergoing scoliosis surgery.

METHODS

A prospective study including forty successive teenagers scheduled for posterior spinal fusion. Patients with scoliosis with a history of hemoglobinopathies, cardiac defects, blood clots, early onset osteoporosis, as well as patients with skeletal dysplasias and nonskeletal dysplastic syndromic entities have been excluded. The protocol was designed for active screening of deep venous thrombosis using color Doppler ultrasonography on a day before surgery and repeated on the 3rd, 7th and 15th day postoperatively. Evaluation of prothrombotic disorders included antithrombin and protein C activities, and total protein S antigen level.

RESULTS

No patient has manifested clinical symptoms of venous thrombosis in our study. Preoperative Doppler and ultrasound examinations were normal in all patients. Although repeated Doppler ultrasonography demonstrated a transient small clot in two patients. Congenital antithrombin deficiency of 5% has been observed in one child only, without the development of deep venous thrombosis.

CONCLUSION

Thromboembolic event seems to be rare after scoliosis surgery. Prophylaxis for venous thrombosis should not be recommended in such patient. But, larger series are required to confirm such results.

摘要

背景

静脉血栓形成在儿童期仍然是一种不常见的疾病。然而,由于多种原因,其发病率似乎在上升。本研究的目的是在接受脊柱侧弯手术的非综合征儿童中检测无症状的深静脉血栓形成和血栓前疾病。

方法

一项前瞻性研究,纳入连续40名计划接受后路脊柱融合术的青少年。排除有血红蛋白病、心脏缺陷、血栓形成、早发性骨质疏松病史的脊柱侧弯患者,以及骨骼发育不良和非骨骼发育不良综合征实体的患者。该方案旨在通过彩色多普勒超声在手术前一天对深静脉血栓形成进行主动筛查,并在术后第3天、第7天和第15天重复进行。对血栓前疾病的评估包括抗凝血酶和蛋白C活性,以及总蛋白S抗原水平。

结果

在我们的研究中,没有患者表现出静脉血栓形成的临床症状。所有患者术前多普勒超声检查均正常。尽管重复多普勒超声检查在两名患者中发现了短暂的小血栓。仅在一名儿童中观察到5%的先天性抗凝血酶缺乏,未发生深静脉血栓形成。

结论

脊柱侧弯手术后血栓栓塞事件似乎很少见。此类患者不建议进行静脉血栓形成的预防。但是,需要更大规模的系列研究来证实这些结果。

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