Department of Obstetrics and Gynaecology and Medical Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway.
Paediatr Perinat Epidemiol. 2010 Jan;24(1):75-8. doi: 10.1111/j.1365-3016.2009.01092.x.
We assessed maternal serum levels of total immunoglobulin E (IgE) in the first, second and third trimester and changes in total IgE levels from first to third trimester in relation to offspring sex. Within a cohort of 29 948 pregnant women, 392 women without a history of pre-eclampsia and with a liveborn child were randomly selected. Information on offspring sex was obtained through linkage to the Medical Birth Registry of Norway. Blood samples from each trimester were analysed for total IgE concentration. Differences in mean levels according to offspring sex were estimated and changes in total IgE levels from first to third trimester were assessed. In all three trimesters there was a tendency of women carrying a male fetus to have a higher mean total IgE level, but significant statistical differences were not reached. The total IgE concentration decreased during pregnancy, but the decrement was less in women carrying a male fetus compared with those who carried a female fetus.
我们评估了孕妇在第一、第二和第三孕期的血清总免疫球蛋白 E（IgE）水平，以及从第一孕期到第三孕期总 IgE 水平的变化与胎儿性别之间的关系。在一个有 29948 名孕妇的队列中，随机选择了 392 名没有子痫前期病史且分娩活婴的女性。通过与挪威医学出生登记处的链接获得了有关胎儿性别的信息。对每个孕期的血样进行总 IgE 浓度分析。根据胎儿性别估计平均水平的差异，并评估从第一孕期到第三孕期总 IgE 水平的变化。在所有三个孕期，携带男胎的女性总 IgE 水平均有升高的趋势，但未达到显著的统计学差异。总 IgE 浓度在怀孕期间下降，但携带男胎的女性下降幅度小于携带女胎的女性。
