Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
Department of Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jan 28;46(1):53-59. doi: 10.11817/j.issn.1672-7347.2021.200468.
Pregnant women in a special physiological period, the body's blood indicators will change to a certain extent. This study aims to explore the changes of serum immunoglobulin levels in healthy pregnant women and establish its reference interval (RI).
A total of 369 healthy pregnant women, who underwent pregnancy examination in the Department of Obstetrics, Second Xiangya Hospital of Central South University from August 2019 to October 2019, were enrolled for this study. They were divided into an early pregnancy group, a middle pregnancy group, and a late pregnancy group according to the pregnancy period, and 123 healthy non-pregnant women were selected as the controls. The levels of immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) were determined by immune transmission turbidities. The level of immunoglobulin E (IgE) was determined by electrochemiluminescence. The differences in immunoglobulin levels between pregnant women and non-pregnant women and among different gestational periods were analyzed, and the RI of serum immunoglobulin level during pregnancy was established.
Compared to the non-pregnant women, the levels of serum IgG, IgM, IgA, and IgE in pregnant women were significantly decreased (all <0.01), with 51.81% for IgG, 43.84% for IgM, 55.80% for IgA, and 49.80% for IgE. Except that the IgG level of late pregnancy group was significantly lower than that of early pregnancy group (<0.05), there were no significant differences in the IgG, IgM, IgA, and IgE levels among the other groups (all >0.05). The RIs of serum IgG in early pregnancy, middle pregnancy, and late pregnancy were 6.02-7.70 g/L, 5.18-6.85 g/L, and 4.58-5.72 g/L, respectively, while the RIs of serum IgM, IgA, and IgE were 0.71-0.93 g/L, 0.90-1.09 g/L, and 68.30-107.69 ng/mL, respectively in pregnant women.
The levels of immunoglobulin in pregnant women are decreased significantly. The establishment of RIs of IgG, IgM, IgA and IgE in healthy pregnant women could provide scientific basis for clinical decision-making.
孕妇处于特殊的生理时期，其机体的血液指标会发生一定程度的变化。本研究旨在探讨健康孕妇血清免疫球蛋白水平的变化，并建立其参考区间（RI）。
选取 2019 年 8 月至 10 月于中南大学湘雅二医院妇产科进行产检的 369 例健康孕妇为研究对象，根据孕期分为早孕期组、中孕期组和晚孕期组，另选取 123 例健康未孕女性作为对照组。采用免疫透射比浊法检测 IgG、IgM 和 IgA 水平，电化学发光法检测 IgE 水平。分析孕妇与非孕妇、不同孕期间免疫球蛋白水平的差异，建立妊娠期间血清免疫球蛋白水平的 RI。
与非孕妇相比，孕妇血清 IgG、IgM、IgA 和 IgE 水平均显著降低（均<0.01），分别降低 51.81%、43.84%、55.80%和 49.80%。除晚孕期组 IgG 水平显著低于早孕期组（<0.05）外，其他各组 IgG、IgM、IgA 和 IgE 水平比较，差异均无统计学意义（均>0.05）。早孕期、中孕期和晚孕期孕妇血清 IgG 的 RI 分别为 6.027.70 g/L、5.186.85 g/L 和 4.585.72 g/L，血清 IgM、IgA 和 IgE 的 RI 分别为 0.710.93 g/L、0.901.09 g/L 和 68.30107.69 ng/mL。
孕妇免疫球蛋白水平显著降低。建立健康孕妇 IgG、IgM、IgA 和 IgE 的 RI，可为临床决策提供科学依据。
