Yan Zhi-tao, Li Nan-fang
Department of Hypertension, the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Dec;31(6):778-81. doi: 10.3881/j.issn.1000-503X.2009.06.026.
Brown adipose tissue contributes to energy balance in humans by generating heat via the mitochondrial uncoupling of lipid oxidation. Currently it is believed that brown adipose has two origins: Myf5-negative progenitor (its source is same as that of white adipocyte) and Myf5-positive progenitor (its source is same as myocyte). Due to the different origins of brown adipocytes, they may be formed via multiple pathways which include the main pathway (by which Myf5-positive progenitors differentiate into brown adipocytes that distribute in classical locations) and alternative pathway (by which Myf5-negative progenitors differentiate into brown adipocytes that distribute in white adipose tissue).
棕色脂肪组织通过脂质氧化的线粒体解偶联产热，从而对人体能量平衡产生影响。目前认为，棕色脂肪有两个来源：Myf5阴性祖细胞（其来源与白色脂肪细胞相同）和Myf5阳性祖细胞（其来源与肌细胞相同）。由于棕色脂肪细胞起源不同，它们可能通过多种途径形成，包括主要途径（Myf5阳性祖细胞分化为分布在经典位置的棕色脂肪细胞）和替代途径（Myf5阴性祖细胞分化为分布在白色脂肪组织中的棕色脂肪细胞）。
