Xie Jian-lan, Zhou Xiao-ge, Jin Yan, Zhu Hong, Zheng Yuan-yuan, Zhang Shu-hong, Zhang Yan-ning, Zhang Xiao-jing, Zheng Xiao-dan
Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China.
Zhonghua Bing Li Xue Za Zhi. 2009 Nov;38(11):754-8.
To study the value of loss of CD10 expression in the diagnosis and differential diagnosis of follicular lymphoma (FL).
One hundred and twenty-six cases of FL and 31 cases of reactive follicular hyperplasia (RFH) were studied with routine microscopy and immunohistochemistry.
Loss of CD10 expression was observed in 37 cases (29.4%) of FL. Three patterns of CD10 loss were demonstrated, as follows: diffuse CD10 loss in all of the neoplastic follicles (33/37, 89%), CD10 loss in most follicles (3/37, 8%) and CD10 loss in only a few follicles (1/37, 3%). In general, loss of CD10 was frequently seen in higher-grade FL. Morphologically, the cases with CD10 loss showed follicular architecture. The neoplastic follicles in high-grade FL were of various sizes and showed irregular margins, while those in low-grade FL were relatively uniform in size with regular margin. Sometimes, the CD10-negative FL cells contained a clear cytoplasm, mimicking monocytoid B cells. On the other hand, CD10 expression was found in all of the 31 cases of RFH studied, with the exception of occasional individual or regressed follicles.
The expression of CD10 differs in FL and RFH. Loss of CD10 expression is seen mainly in FL. It is thus considered as a valuable parameter in differentiating between FL and RFH.
研究CD10表达缺失在滤泡性淋巴瘤（FL）诊断及鉴别诊断中的价值。
采用常规显微镜检查及免疫组织化学方法对126例FL和31例反应性滤泡增生（RFH）进行研究。
在126例FL中，37例（29.4%）出现CD10表达缺失。CD10缺失呈现三种模式：所有肿瘤性滤泡均弥漫性CD10缺失（33/37，89%）、多数滤泡CD10缺失（3/37，8%）及少数滤泡CD10缺失（1/37，3%）。总体而言，CD10缺失在高级别FL中更为常见。形态学上，CD10缺失的病例呈现滤泡结构。高级别FL中的肿瘤性滤泡大小各异，边缘不规则，而低级别FL中的肿瘤性滤泡大小相对均匀，边缘规则。有时，CD10阴性的FL细胞含有清晰的胞质，类似单核样B细胞。另一方面，在研究的31例RFH中，除偶尔个别或退行性滤泡外，其余均有CD10表达。
FL和RFH中CD10的表达不同。CD10表达缺失主要见于FL。因此，它被认为是鉴别FL和RFH的一个有价值的参数。
