Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Chin Med J (Engl). 2009 Oct 20;122(20):2433-7.
Dysembryoplastic neuroepithelial tumor (DNT) is a rare benign neoplasm of the central nervous system affecting young people. A correct preoperative diagnosis is helpful for planning surgical strategies and improving prognosis. The purpose of this study was to characterize DNTs using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) and to analyze the value of these two techniques in the diagnosis of DNTs.
MR images of 13 patients with DNTs were reviewed retrospectively; and five of the patients also underwent MRS. Tumors were confirmed by surgery. The distribution, extension and signal features of the lesions were assessed, and the MRS results were analyzed.
All tumors were supratentorial. The cortex was the main area involved, with nine tumors located in the temporal lobe, three in the frontal lobe, and one on the boundary between the temporal and occipital lobes. All cases had decreased signal intensity on T1-weighted MR images and increased signal intensity on T2-weighted images. On fluid attenuated inversion recovery weighted images, the hyperintense "ring sign" and internal septation of the lesion were seen in 9 cases. Eight tumors had well-demarcated borders. Peritumoral edema or mass effect was absent in all cases. A contrast enhancement examination was performed in 9 cases. Contrast enhancement was absent in five cases, and four cases showed significant enhancement. The MRS showed a low N-acetylaspartate peak and a lack of elevated choline-containing component (Cho) or Cho-Cr ratio (Cho/Cr) in five patients.
The MRI findings of DNTs were stereotypical. The combination of MRI and MRS techniques were helpful in making a correct presurgical diagnosis.
胚胎发育不良性神经上皮肿瘤（DNT）是一种罕见的中枢神经系统良性肿瘤，好发于年轻人。正确的术前诊断有助于制定手术策略并改善预后。本研究旨在通过磁共振成像（MRI）和磁共振波谱（MRS）来描述 DNT 的特征，并分析这两种技术在 DNT 诊断中的价值。
回顾性分析 13 例 DNT 患者的 MRI 图像，其中 5 例患者还进行了 MRS 检查。肿瘤经手术证实。评估病变的分布、范围和信号特征，并分析 MRS 结果。
所有肿瘤均位于幕上。皮层是主要受累区域，9 个肿瘤位于颞叶，3 个位于额叶，1 个位于颞叶和枕叶交界处。所有病例 T1 加权 MRI 图像上信号强度降低，T2 加权图像上信号强度增高。液体衰减反转恢复（FLAIR）加权图像上，9 例可见病变呈高信号的“环征”和内部分隔。8 个肿瘤边界清楚。所有病例均无瘤周水肿或占位效应。9 例行增强检查，5 例未见强化，4 例明显强化。MRS 显示 5 例患者的 N-乙酰天门冬氨酸（NAA）峰降低，胆碱（Cho）含量升高或 Cho/Cr 比值升高。
DNT 的 MRI 表现具有特征性。MRI 和 MRS 技术的结合有助于做出正确的术前诊断。
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