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胚胎发育不良性神经上皮肿瘤的复发与组织学演变：一例报告并文献复习

Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature.

作者信息

Chao Lv, Tao Xu Bo, Jun Yang Kai, Xia Han Hui, Wan Wang Ke, Tao Qi Song

机构信息

Department of Neurosurgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

出版信息

Oncol Lett. 2013 Oct;6(4):907-914. doi: 10.3892/ol.2013.1480. Epub 2013 Jul 22.

DOI:10.3892/ol.2013.1480
PMID:24137435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3796405/
Abstract

Studies of recurrent dysembryoplastic neuroepithelial tumors (DNTs) are distinctly rare. The present study reports the case of a 15-year-old female with a temporal lobe DNT, which recurred and transformed into an astrocytoma (WHO grade II) five years after an initial gross total resection (GTR). Furthermore, all the previous studies on recurrent DNT are reviewed. Although the majority of DNT cases demonstrate benign behavior, recurrent DNTs have been observed following a GTR of the tumor. Patients do not appear to benefit from post-operative adjuvant therapy, and inappropriate radiotherapy or chemotherapy may result in tumor recurrence or malignant transformation. The prognosis is favorable if a GTR of the recurrent tumor is achieved. The use of regular imaging examinations and the maintenance of a long-term follow-up is of importance following a tumor resection.

摘要

复发性胚胎发育不良性神经上皮肿瘤（DNTs）的研究极为罕见。本研究报告了一例15岁女性颞叶DNT病例，该病例在初次肉眼全切（GTR）术后五年复发并转变为星形细胞瘤（WHO二级）。此外，还对之前所有关于复发性DNT的研究进行了综述。尽管大多数DNT病例表现为良性行为，但肿瘤GTR术后仍观察到复发性DNT。患者似乎无法从术后辅助治疗中获益，不恰当的放疗或化疗可能导致肿瘤复发或恶变。如果复发性肿瘤实现GTR，预后良好。肿瘤切除术后，定期进行影像学检查并长期随访很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/06cf364ef423/OL-06-04-0907-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/d2e873b25f1b/OL-06-04-0907-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/27fc53e82286/OL-06-04-0907-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/beef40c5e4f0/OL-06-04-0907-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/4e4a9d1574db/OL-06-04-0907-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/5b03737d4095/OL-06-04-0907-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/0a0ce9649109/OL-06-04-0907-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/06cf364ef423/OL-06-04-0907-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/d2e873b25f1b/OL-06-04-0907-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/27fc53e82286/OL-06-04-0907-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/beef40c5e4f0/OL-06-04-0907-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/4e4a9d1574db/OL-06-04-0907-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/5b03737d4095/OL-06-04-0907-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/0a0ce9649109/OL-06-04-0907-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c32/3796405/06cf364ef423/OL-06-04-0907-g06.jpg

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