Shan Xiao-feng, Cai Zhi-gang, Wu Li-ling, Yu Guang-yan
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Sep;44(9):548-52.
To investigate the effect of botulinum toxin-A (BTX-A) on secretion of parasympathetic denervated rabbit submandibular gland.
Twenty-four rabbits were divided into 3 groups: control (n = 4), parasympathetic denervated submandibular gland (n = 4), and parasympathetic denervated submandibular gland with 5 U BTX-A injection (n = 16). Secretion flow was measured by Schirmer test. Composition of saliva was detected by biochemical method.
Secretion of parasympathetic denervated submandibular gland increased by 139.0% in rest time (P < 0.01), but decreased by 64.2% in feeding time (P < 0.01) compared with controls. Secretion of submandibular gland decreased in rest time 1, 2, 4, and 12 weeks after BTX-A injection compared with that of parasympathetic denervated submandibular gland without injection (P < 0.05), which was also the same in feeding time 1 and 2 week after injection (P < 0.05). The concentrations of amylase, sodium, potassium, chloride and protein of saliva were not changed after BTX-A injection.
BTX-A could decrease the secretion of parasympathetic denervated submandibular gland.
探讨A型肉毒毒素（BTX-A）对去副交感神经支配的兔下颌下腺分泌的影响。
将24只兔分为3组：对照组（n = 4）、去副交感神经支配的下颌下腺组（n = 4）和去副交感神经支配的下颌下腺注射5 U BTX-A组（n = 16）。采用泪液分泌试验测量分泌流量。用生化方法检测唾液成分。
与对照组相比，去副交感神经支配的下颌下腺在休息时分泌增加139.0%（P < 0.01），但在进食时分泌减少64.2%（P < 0.01）。与未注射BTX-A的去副交感神经支配的下颌下腺相比，注射BTX-A后1、2、4和12周休息时下颌下腺分泌减少（P < 0.05），注射后1和2周进食时分泌也减少（P < 0.05）。注射BTX-A后唾液淀粉酶、钠、钾、氯和蛋白质浓度未改变。
BTX-A可减少去副交感神经支配的下颌下腺的分泌。
