Qi Wei, Yang Ning-Yan, Shan Xiao-Feng, Fu Feng-Ying, Wu Li-Ling, Yu Guang-Yan
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Sep;46(9):519-23. doi: 10.3760/cma.j.issn.1002-0098.2011.09.003.
To investigate the effect of parasympathectomy on secretion of submandibular glands and the feasibility of treatment for xerostomia in rats.
Twenty Sprague-Dawley male rats weighing 200 - 300 g were randomly divided into the experimental group (n = 12), in which the right chorda-lingual nerve was cut, and the control group (n = 8). The secretion of submandibular gland was measured for 5 min by Schirmer test for both groups.
The stimulated saliva flow rate decreased on 1st, 12th and 24th week after denervation in the right operated submandibular glands (P < 0.05). No difference in secretion was found between the left non-operated glands and the control group. Comparing with the left non-operated gland and the control gland, the saliva flow rate at rest in the right operated submandibular gland increased on the 1st, 12th and 24th week (P < 0.05).
After parasympathectomy of rat submandibular glands, the saliva flow rate at rest increased in the denervated gland, which suggests that parasympathectomy of submandibular gland might be used as a therapy for xerostomia.
探讨去交感神经术对大鼠下颌下腺分泌的影响及治疗口干症的可行性。
将20只体重200 - 300 g的雄性Sprague-Dawley大鼠随机分为实验组（n = 12），切断右侧鼓索神经；对照组（n = 8）。两组均采用Schirmer试验测量下颌下腺5分钟的分泌量。
右侧手术侧下颌下腺去神经支配后第1、12和24周，刺激唾液流速降低（P < 0.05）。左侧未手术腺体与对照组之间的分泌无差异。与左侧未手术腺体和对照腺体相比，右侧手术侧下颌下腺在第1、12和24周静息时的唾液流速增加（P < 0.05）。
大鼠下颌下腺去交感神经术后，去神经支配腺体静息时的唾液流速增加，提示下颌下腺去交感神经术可能可用于治疗口干症。
