PTEN/mTOR 与轴突再生。

PTEN/mTOR and axon regeneration.

机构信息

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Exp Neurol. 2010 May;223(1):45-50. doi: 10.1016/j.expneurol.2009.12.032. Epub 2010 Jan 14.

DOI:10.1016/j.expneurol.2009.12.032

PMID:20079353

Abstract

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury.

摘要

轴突再生在周围神经系统和中枢神经系统中是如何被控制的仍然难以捉摸。对发育过程中轴突生长和损伤后轴突再生的机制研究揭示了 PTEN 依赖性分子机制的共性。该途径可能会影响神经元胞体中的过程，如 mTOR 调节的蛋白质翻译，以及轴突中的过程，如细胞骨架组装。在这篇综述中，我们将讨论这些过程在轴突生长调控中的作用的最新认识，以及它们在促进损伤后轴突再生中的潜在意义。