Department of Biophysics, School of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
Neurosci Res. 2010 May;67(1):1-7. doi: 10.1016/j.neures.2010.01.002. Epub 2010 Jan 15.
The dentate nucleus represents the most lateral of the four cerebellar nuclei that serve as major relay centres for fibres coming from the cerebellar cortex. Although many relevant findings regarding to the structure, neuronal morphology and cytoarchitectural development of the dentate nucleus have been presented so far, very little quantitative information has been collected on the types of large neurons in the human dentate nucleus. In the present study we qualitatively analyze our sample of large neurons according to their morphology and topology, and classify these cells into four types. Then, we quantify the morphology of such cell types taking into account seven morphometric parameters which describe the main properties of the cell soma, dendritic field and dendrite arborization. By performing appropriate statistics we prove out our classification of the large dentate neurons in the adult human. To the best of our knowledge, this study represents the first attempt of quantitative analysis of morphology and classification of the large neurons in the adult human dentate nucleus.
齿状核是四个小脑核中最外侧的一个，作为来自小脑皮层纤维的主要中继中心。尽管目前已经提出了许多关于齿状核的结构、神经元形态和细胞构筑发育的相关发现，但关于人类齿状核中大型神经元的类型，很少有定量信息被收集。在本研究中，我们根据形态和拓扑结构对我们的大型神经元样本进行定性分析，并将这些细胞分为四种类型。然后，我们考虑七个形态计量参数来量化这些细胞类型的形态，这些参数描述了细胞体、树突场和树突分支的主要特性。通过进行适当的统计学分析，我们证明了我们对成人齿状核中大型神经元的分类。据我们所知，这项研究代表了对成人齿状核中大型神经元的形态定量分析和分类的首次尝试。
