Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Neurosci Res. 2010 May;67(1):72-9. doi: 10.1016/j.neures.2010.01.003. Epub 2010 Jan 15.
It is known that emotion and reward motivation promote long-term memory formation. It remains unclear, however, how and where emotion and reward are integrated during episodic memory encoding. In the present study, subjects were engaged in intentional encoding of photographs under four different conditions that were made by combining two factors (emotional valence, negative or neutral; and monetary reward value, high or low for subsequent successful recognition) during H2 15O positron emission tomography (PET) scanning. As for recognition performance, we found significant main effects of emotional valence (negative>neutral) and reward value (high value>low value), without an interaction between the two factors. Imaging data showed that the left amygdala was activated during the encoding conditions of negative pictures relative to neutral pictures, and the left orbitofrontal cortex was activated during the encoding conditions of high reward pictures relative to low reward pictures. In addition, conjunction analysis of these two main effects detected right hippocampal activation. Although we could not find correlations between recognition performance and activity of these three regions, we speculate that the right hippocampus may integrate the effects of emotion (processed in the amygdala) and monetary reward (processed in the orbitofrontal cortex) on episodic memory encoding.
已知情绪和奖励动机促进长期记忆的形成。然而，在情景记忆编码过程中，情绪和奖励是如何以及在何处被整合的，目前仍不清楚。在本研究中，受试者在 H2 15O 正电子发射断层扫描（PET）扫描期间进行了四种不同条件下的照片有意编码，这四种条件是通过结合两个因素（情绪效价，负性或中性；和货币奖励值，高或低，以用于后续成功识别）来实现的。就识别性能而言，我们发现情绪效价（负性>中性）和奖励价值（高值>低值）有显著的主效应，而这两个因素之间没有相互作用。成像数据显示，在负性图片的编码条件下，左侧杏仁核被激活，而在高奖励图片的编码条件下，左侧眶额皮层被激活。此外，对这两个主要效应的联合分析检测到右侧海马的激活。尽管我们无法找到识别性能与这三个区域的活动之间的相关性，但我们推测右侧海马可能整合了情绪（在杏仁核中处理）和货币奖励（在眶额皮层中处理）对情景记忆编码的影响。
