转录因子结合强度调节转录网络中的共变异。
The strength of transcription-factor binding modulates co-variation in transcriptional networks.
机构信息
University of Southern California, Program in Molecular and Computational Biology, Los Angeles, CA 90089, USA.
出版信息
Trends Genet. 2010 Feb;26(2):51-3. doi: 10.1016/j.tig.2009.12.005. Epub 2010 Jan 18.
Abstract
An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the strength of DNA binding for individual TFs translates into regulatory control, or whether a different set of binding motifs is used for strongly regulated modules. Here we integrate two publicly available data sets in Drosophila melanogaster, as well as conduct novel analyses, to address these questions.
摘要
转录组在个体间的表达水平存在明显差异。转录因子（TF）的表达和 DNA 结合导致下游靶基因的细胞特异性激活和抑制，并且 TF 的表达水平在个体间存在差异。然而，目前尚不清楚单个 TF 的 DNA 结合强度如何转化为调控控制，或者是否使用不同的结合基序来调控强调节模块。在这里，我们整合了果蝇中两个公开可用的数据集，并进行了新的分析，以解决这些问题。
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