Vacic Vladimir, Iakoucheva Lilia M, Radivojac Predrag
Computer Science and Engineering Department, University of California Riverside, CA, USA.
Bioinformatics. 2006 Jun 15;22(12):1536-7. doi: 10.1093/bioinformatics/btl151. Epub 2006 Apr 21.
Two Sample Logo is a web-based tool that detects and displays statistically significant differences in position-specific symbol compositions between two sets of multiple sequence alignments. In a typical scenario, two groups of aligned sequences will share a common motif but will differ in their functional annotation. The inclusion of the background alignment provides an appropriate underlying amino acid or nucleotide distribution and addresses intersite symbol correlations. In addition, the difference detection process is sensitive to the sizes of the aligned groups. Two Sample Logo extends WebLogo, a widely-used sequence logo generator. The source code is distributed under the MIT Open Source license agreement and is available for download free of charge.
双样本序列标志是一种基于网络的工具，可检测并显示两组多序列比对中特定位置符号组成的统计学显著差异。在典型情况下，两组比对序列会共享一个共同基序，但在功能注释上有所不同。背景比对的纳入提供了合适的潜在氨基酸或核苷酸分布，并解决了位点间符号相关性问题。此外，差异检测过程对比对组的大小敏感。双样本序列标志扩展了广泛使用的序列标志生成器WebLogo。其源代码根据麻省理工学院开源许可协议发布，可免费下载。
