p53 靶基因的差异调控：这是（核心启动子）的基础。
Differential regulation of p53 target genes: it's (core promoter) elementary.
机构信息
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, The University of Colorado at Boulder, Boulder, Colorado 80309, USA.
出版信息
Genes Dev. 2010 Jan 15;24(2):111-4. doi: 10.1101/gad.1893610.
Abstract
p53 is a pleiotropic transcription factor driving a flexible transcriptional program that mediates disparate cellular responses to stress, including cell cycle arrest and apoptosis. The mechanisms by which p53 differentially regulates its diverse target genes remain poorly understood. In this issue of Genes & Development, Morachis and colleagues (pp. 135-147) demonstrate the critical role of core promoter elements at p53 target loci, in that they dictate differential RNA polymerase II recruitment and activity in a p53-autonomous fashion.
摘要
p53 是一种多效转录因子，可驱动灵活的转录程序，介导细胞对压力的不同反应，包括细胞周期停滞和细胞凋亡。p53 差异调节其多种靶基因的机制仍知之甚少。在本期《基因与发育》中，Morachis 及其同事（第 135-147 页）证明了 p53 靶基因座核心启动子元件的关键作用，即它们以 p53 自主的方式决定差异 RNA 聚合酶 II 的募集和活性。
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1
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2
Control of inducible gene expression by signal-dependent transcriptional elongation.
Cell. 2009 Jul 10;138(1):129-45. doi: 10.1016/j.cell.2009.05.047.
3
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.
Genes Dev. 2009 Jun 1;23(11):1364-77. doi: 10.1101/gad.1795709.
4
Blinded by the Light: The Growing Complexity of p53.
Cell. 2009 May 1;137(3):413-31. doi: 10.1016/j.cell.2009.04.037.
5
Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation.
Cell Cycle. 2008 Aug;7(15):2427-33. doi: 10.4161/cc.6420. Epub 2008 Jun 9.
6
The RNA polymerase II core promoter - the gateway to transcription.
Curr Opin Cell Biol. 2008 Jun;20(3):253-9. doi: 10.1016/j.ceb.2008.03.003. Epub 2008 Apr 22.
7
A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response.
Nucleic Acids Res. 2008 Mar;36(5):1415-28. doi: 10.1093/nar/gkm1046. Epub 2008 Jan 10.
8
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes.
Cell. 2007 Aug 24;130(4):638-50. doi: 10.1016/j.cell.2007.08.001.
9
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
Cell. 2007 Aug 24;130(4):624-37. doi: 10.1016/j.cell.2007.06.013.
10
Divergent evolution of human p53 binding sites: cell cycle versus apoptosis.
PLoS Genet. 2007 Jul;3(7):e127. doi: 10.1371/journal.pgen.0030127. Epub 2007 Jun 15.
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