p53 靶基因的差异调控：这是（核心启动子）的基础。
Differential regulation of p53 target genes: it's (core promoter) elementary.
机构信息
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, The University of Colorado at Boulder, Boulder, Colorado 80309, USA.
出版信息
Genes Dev. 2010 Jan 15;24(2):111-4. doi: 10.1101/gad.1893610.
Abstract
p53 is a pleiotropic transcription factor driving a flexible transcriptional program that mediates disparate cellular responses to stress, including cell cycle arrest and apoptosis. The mechanisms by which p53 differentially regulates its diverse target genes remain poorly understood. In this issue of Genes & Development, Morachis and colleagues (pp. 135-147) demonstrate the critical role of core promoter elements at p53 target loci, in that they dictate differential RNA polymerase II recruitment and activity in a p53-autonomous fashion.
摘要
p53 是一种多效转录因子，可驱动灵活的转录程序，介导细胞对压力的不同反应，包括细胞周期停滞和细胞凋亡。p53 差异调节其多种靶基因的机制仍知之甚少。在本期《基因与发育》中，Morachis 及其同事（第 135-147 页）证明了 p53 靶基因座核心启动子元件的关键作用，即它们以 p53 自主的方式决定差异 RNA 聚合酶 II 的募集和活性。
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