Laskowska Marzena, Laskowska Katarzyna, Leszczyńska-Gorzelak Bozena, Oleszczuk Jan
Department of Obstetrics and Perinatology Medical University of Lublin, ul. Jaczewskiego 8, 20-950 Lublin.
Med Wieku Rozwoj. 2009 Jul-Sep;13(3):212-7.
The aim of this study was the comparative analysis of the sP-selectin in pregnancies complicated by severe preeclampsia with intrauterine normal growth and small-for-gestational-age foetus.
The study was carried out on 14 patients with preeclampsia complicated by intrauterine growth retardation (group PI) and 13 preeclamptic patients with appropriate-for-gestational-age weight infants (group P). The control group consisted of 13 healthy normotensive pregnant patients with singleton uncomplicated pregnancies (group C). Maternal serum soluble P-selectin concentrations were estimated using sandwich ELISA assay according to the manufacturer's instructions.
Pregnant women with severe preeclampsia had higher maternal serum sP-selectin levels than the normotensive controls. The sP-selectin levels were highest and statistically significant in preeclamptic patients with appropriate-for-gestational-age weight infants.
Our findings indicate an association between the increased levels of sP-selectin and severe preeclampsia. However, further studies are required to validate this association and explore the possibility of clinical importance and causative role of sP-selectin in the pathogenesis of preeclampsia.
本研究旨在对妊娠合并重度子痫前期且胎儿宫内生长正常及小于胎龄儿的患者进行可溶性P选择素（sP - 选择素）的比较分析。
本研究选取了14例合并胎儿宫内生长受限的子痫前期患者（PI组）以及13例胎儿体重符合孕周的子痫前期患者（P组）。对照组由13例血压正常的健康单胎妊娠孕妇组成（C组）。根据制造商的说明，采用夹心酶联免疫吸附测定法（ELISA）估算孕妇血清可溶性P选择素浓度。
重度子痫前期孕妇的母体血清sP - 选择素水平高于血压正常的对照组。在胎儿体重符合孕周的子痫前期患者中，sP - 选择素水平最高且具有统计学意义。
我们的研究结果表明sP - 选择素水平升高与重度子痫前期之间存在关联。然而，需要进一步研究来验证这种关联，并探讨sP选择素在子痫前期发病机制中的临床重要性和致病作用的可能性。
