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为感染艾滋病毒的妇女扩大计划生育方案的获得机会的益处和成本。

Benefits and costs of expanding access to family planning programs to women living with HIV.

机构信息

Harvard University School of Public Health, Boston, Massachusetts, USA.

出版信息

AIDS. 2009 Nov;23 Suppl 1:S123-30. doi: 10.1097/01.aids.0000363785.73450.5a.

Abstract

OBJECTIVE

This analysis models the potential benefits and costs of adding family planning to national strategies for achieving universal access to programs to prevent mother-to-child HIV transmission.

METHODS

We assume a service delivery perspective and estimate the cost-effectiveness of programs to reduce the number of HIV-infected children through using antiretroviral prophylaxis to prevent perinatal transmission, and of family planning programs to avert additional infant infections not already averted by antiretroviral prophylaxis, as well as of family planning to reduce the number of total unintended births to women living with HIV. Data are presented from the 139 countries included in the 2008 Annual United Nations Joint Programme on HIV/AIDS Report, although the main results are for the 14 countries with the largest number of HIV-infected pregnant women.

RESULTS

Programs to prevent perinatal HIV transmission would, if accessed by all women in need with the most efficacious antiretroviral regimen available, prevent over 240,000 dollars infant HIV infections in the top 14 countries (over 300,000 globally) at an estimated cost of over 131 million dollars (208 million dollars globally). However, almost 72,000 infant HIV infections would still occur in the 14 countries (over 90,000 globally) that could have been averted by preventing unintended pregnancies at a cost of only about 26 million dollars (over 33 million dollars globally). If all unintended births (whether or not resulting in HIV-infected children) to HIV-positive women were prevented with family planning, the cost per birth averted would be 61 dollars in the 14 countries (63 dollars globally).

CONCLUSION

This analysis suggests that national strategies should adopt a comprehensive approach to preventing mother-to-child transmission and thus focus on preventing perinatal HIV transmission as well as unintended pregnancies. Family planning is cost-effective for preventing HIV transmission and unintended pregnancies and will also reduce infant and maternal mortality and result in fewer orphans.

摘要

目的

本分析旨在评估将计划生育纳入实现普及母婴传播艾滋病毒预防规划的国家战略的潜在效益和成本。

方法

我们从服务提供的角度出发,对通过使用抗逆转录病毒预防药物减少因母婴传播而感染艾滋病毒的儿童数量的方案、通过计划生育避免因抗逆转录病毒预防而未避免的其他婴儿感染的方案,以及通过计划生育减少艾滋病毒感染妇女意外妊娠数量的方案的成本效益进行了估计。数据来源于 2008 年联合国艾滋病规划署/联合国儿童基金会联合年度报告所涵盖的 139 个国家,但主要结果是针对感染艾滋病毒孕妇数量最多的 14 个国家。

结果

如果所有有需要的妇女都能获得最有效的抗逆转录病毒方案,预防母婴传播的方案将可避免前 14 个国家(全球超过 300 万)超过 24 万名婴儿感染艾滋病毒,费用估计超过 1.31 亿美元(全球超过 2.08 亿美元)。然而,在可通过避免意外怀孕而避免的 14 个国家(全球超过 9 万)中,仍将有近 7.2 万名婴儿感染艾滋病毒,其费用仅约为 2600 万美元(全球超过 3300 万美元)。如果通过计划生育避免所有艾滋病毒阳性妇女的意外妊娠(无论是否导致感染艾滋病毒的儿童),则可避免的每例妊娠的成本为前 14 个国家的 61 美元(全球 63 美元)。

结论

本分析表明,国家战略应采取综合方法预防母婴传播,因此应侧重于预防围产期艾滋病毒传播以及意外妊娠。计划生育在预防艾滋病毒传播和意外妊娠方面具有成本效益,还将降低婴儿和产妇死亡率,并减少孤儿人数。

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