Ramirez-Gonzalez M D, Barna I, Wiegant V M, de Jong W
Rudolf Magnus Institute for Pharmacology, University of Utrecht, The Netherlands.
Life Sci. 1991;48(14):1371-7. doi: 10.1016/0024-3205(91)90433-c.
Analgesia and anaesthesia produced by fentanyl, urethane and ether, but not pentobarbital, occurred concomitantly with an increase in the concentration of plasma beta-endorphin like immunoreactivity (BEIR), probably of pituitary origin. This increase was not associated with significant changes in pituitary or brainstem beta-endorphin content. Pretreatment with naloxone caused a reduction in plasma BEIR increase following Hypnorm, ether and urethane; and in the analgesia following Hypnorm and urethane. Pentobarbital, alone or in combination with naloxone, did not increase the concentration of plasma beta-endorphin. These results may indicate participation of endogenous opioids in the mechanism of action of urethane.
芬太尼、乌拉坦和乙醚可产生镇痛和麻醉作用，但戊巴比妥不能，同时血浆中β-内啡肽样免疫反应性（BEIR）浓度升高，可能源于垂体。这种升高与垂体或脑干β-内啡肽含量的显著变化无关。纳洛酮预处理可使海洛因、乙醚和乌拉坦给药后血浆BEIR的升高以及海洛因和乌拉坦给药后的镇痛作用减弱。戊巴比妥单独使用或与纳洛酮联合使用均不会增加血浆β-内啡肽的浓度。这些结果可能表明内源性阿片类物质参与了乌拉坦的作用机制。
