Barna I, Acs Z, Koenig J I
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Life Sci. 1993;52(17):1417-24. doi: 10.1016/0024-3205(93)90065-b.
Administration of Hypnorm, an anaesthetic containing the known mu-opiate receptor agonist fentanyl, elicited dose- and time-related elevation of plasma ACTH, beta-endorphin and corticosterone levels in 10-day old rat pups. Pretreatment with specific antibodies (raised against CRH, AVP and ACTH resp.) revealed that Hypnorm administration activated the ACTH-corticosterone system in the 10-day old rat and its effect is mediated by CRH and/or AVP. Hypnorm anaesthesia was associated with significant decrease in the ACTH and beta-endorphin levels in the pituitary lobes as well as in beta-endorphin content of the hypothalamus and medulla oblongata. Latter results may indicate that the beta-endorphinergic system in the brain of the 10-day old rat is activated by Hypnorm, an effect most probably elicited by the opiate agonist fentanyl.
给10日龄的幼鼠注射Hypnorm（一种含有已知μ-阿片受体激动剂芬太尼的麻醉剂），可引起血浆促肾上腺皮质激素（ACTH）、β-内啡肽和皮质酮水平出现与剂量和时间相关的升高。用特异性抗体（分别针对促肾上腺皮质激素释放激素（CRH）、血管加压素（AVP）和ACTH制备）进行预处理后发现，注射Hypnorm可激活10日龄幼鼠的ACTH-皮质酮系统，其作用由CRH和/或AVP介导。Hypnorm麻醉与垂体叶中ACTH和β-内啡肽水平以及下丘脑和延髓中β-内啡肽含量的显著降低有关。后一结果可能表明，10日龄幼鼠大脑中的β-内啡肽能系统被Hypnorm激活，这种作用很可能是由阿片激动剂芬太尼引起的。
