Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Spine (Phila Pa 1976). 2010 Feb 15;35(4):439-46. doi: 10.1097/BRS.0b013e3181bdafb9.
A subanalysis study.
The purpose of this study was to determine the impact of multilevel lumbar stenosis with or without degenerative spondylolisthesis compared to single level disease on patients' baseline symptoms and clinical outcomes over time.
Previous studies have demonstrated better clinical outcomes with surgery than nonoperative treatment in patients with spinal stenosis with or without degenerative spondylolisthesis. However, the impact of multilevel stenosis has not been studied in these patients.
The results from a multicenter randomized and observational study, the Spine Patient Outcomes Research Trial (SPORT) comparing surgical versus nonoperative treatment for spinal stenosis with or without spondylolisthesis, were analyzed. The primary outcomes measures were the Bodily Pain and Physical Function scales of the Medical Outcomes Study 36-item Short-Form General Health Survey (SF-36) and the modified Oswestry Disability Index at 6 weeks, 3 months, 6 months, 1 year, and 2 years. Secondary outcome measures included the stenosis bothersomeness index, leg pain bothersomeness, low back pain bothersomeness, and patient satisfaction.
In this subanalysis of SPORT data, multilevel spinal stenosis did not demonstrate worse baseline symptoms or worse treatment outcomes in isolated spinal stenosis; however, if concomitant degenerative spondylolisthesis existed, patients with only single level stenosis tended to improve more than those with multilevel stenosis, particularly after surgery.
Patients with spinal stenosis without associated degenerative spondylolisthesis or scoliosis can be managed nonoperatively irrespective of the number of levels involved. If surgery is performed, the number of levels treated does not predict outcome. In contrast, patients with concomitant degenerative spondylolisthesis and single level stenosis do better surgically than those with additional levels of stenosis. This study emphasizes the importance of shared decision-making between the physician and patient when considering treatment for spinal stenosis.
亚组分析研究。
本研究旨在确定多节段腰椎狭窄症(伴或不伴退行性腰椎滑脱)与单节段疾病相比,对患者基线症状和随时间推移的临床结果的影响。
先前的研究表明,与非手术治疗相比,脊柱狭窄症(伴或不伴退行性腰椎滑脱)患者接受手术治疗的临床效果更好。然而,这些患者的多节段狭窄的影响尚未在研究中进行探讨。
对多中心随机观察性研究——脊柱患者结局研究试验(SPORT)的结果进行分析,该研究比较了手术与非手术治疗伴或不伴退行性腰椎滑脱的脊柱狭窄症患者。主要结局测量指标是医疗结局研究 36 项简短健康调查问卷(SF-36)的身体疼痛和生理功能量表以及改良 Oswestry 功能障碍指数,测量时间为 6 周、3 个月、6 个月、1 年和 2 年。次要结局测量指标包括狭窄困扰指数、腿部疼痛困扰、下腰痛困扰和患者满意度。
在 SPORT 数据的这项亚组分析中,多节段脊柱狭窄症并未在单纯脊柱狭窄症中表现出更差的基线症状或更差的治疗结局;然而,如果存在伴发性退行性腰椎滑脱,仅有单节段狭窄的患者倾向于比多节段狭窄的患者改善得更多,特别是在接受手术后。
无伴发性退行性腰椎滑脱或脊柱侧凸的脊柱狭窄症患者可以选择非手术治疗,而不论受累节段的数量如何。如果进行手术,治疗的节段数量并不能预测结果。相比之下,伴发性退行性腰椎滑脱和单节段狭窄的患者接受手术治疗的效果要好于伴发其他节段狭窄的患者。这项研究强调了在考虑脊柱狭窄症治疗时,医生和患者之间进行共同决策的重要性。